Simpson, J. C., Dascher, C., Roberts, L. M., Lord, J. M. and Balch, W. W. (1995). Ricin
cytotoxity is sensitive to
recycling between the ER and the Golgi complex. J. Biol. Chem. 270, 20,078-20,083.
Sphyris, N. J., Lord, J. M., Wales, R. and Roberts, L. M. (1995). Mutational analysis of
the Ricinus lectin B chains. J.
Biol. Chem. 270, 20292-20298.
Pitcher, C., Roberts, L. M., Fawell, S., Zdanovsky, A. G., FitzGerald, D. J. and Lord, J.
M. (1995). Generation of a
potent chimeric toxin by replacement of domain III of Pseudomonas exotoxin with ricin A
chain-KDEL. Bioconjugate.
Chem. 6, 624-629.
Simpson, J. C., Lord, J. M. and Roberts, L. M. (1995). Point mutations in the hydrophobic
C-terminal region of ricin A
chain indicate that Pro250 plays a key role in membrane translocation. Eur. J. Biochem.
232, 485-463.
Chaddock, J. A., Roberts, L. M., Jungnickel, B. and Lord, J. M. (1995) A hydrophobic
region of ricin A chain which
may have a role in membrane translocation can function as an efficient non-cleaved signal
peptide. Biochem. Biophys.
Res. Comm. 217, 68-73
Chaddock, J. A., Monzingo, A. F., Robertus, J., Lord, J. M. and Roberts, L. M. (1996)
Major structural differences
between pokeweed antiviral protein and ricin A-chain do not account for their differing
ribosome specificity. Eur. J.
Biochem. 235, 159-166
Lord, J. M. and Roberts, L. M. (1996) The intracellular transport of ricin: why mammalian
cells are killed and how
Ricinus cells survive. Plant Physiol. Biochem. 34, 253-261
Walker, D., Chaddock, A. M., Chaddock, J. A., Roberts, L. M., Lord, J. M. and Robinson, C.
(1996) Ricin A chain
fused to a chloroplast-targeting signal is unfolded on the chloroplast surface prior to
import across the envelope
membranes. J. Biol. Chem. 271, 4082-4085
Simpson, J. C., Roberts, L. M. and Lord, J. M. (1996) Free ricin A chain reaches an early
compartment of the
secretory pathway before it enters the cytosol. Exp. Cell Res. 229, 447-451
Zhan, J., de Sousa, M., Chaddock, J. A., Roberts, L. M. and Lord, J. M. (1997) Restoration
of lectin activity to a non
glycosylated ricin B chain mutant by the introduction of a novel glycosylation site. FEBS
Letters 407, 271-274
Williams, J. M., Lea, N., Lord, J. M., Roberts, L. M. and Taylor, M.(1997) Comparison of
ribosome inactivating
proteins in the induction of apoptosis. Toxicology Letters 91, 121-127
Beaumelle, B., Taupiac, M-P., Lord, J. M. and Roberts, L. M. (1997) Ricin A chain can
transport unfolded
dihydrofolate reductase into the cytosol. J. Biol. Chem. 272, 22097-22102
Simpson, J. C., Smith, D. C., Roberts, L. M. and Lord, J. M. (1997) Expression of mutant
dynamin protects cells
against diphtheria toxin but not against ricin. Exp. Cell Res. 239, 293-300
Frigerio, L., Vitale, A., Lord. J. M., Ceriotti, A. and Roberts, L. M. (1998) Free ricin A
chain, proricin and native toxin
have different cellular fates when expressed in tobacco protoplasts J. Biol. Chem. 273,
14194-14199
Lord, J. M. and Roberts, L. M. (1998) Retrograde transport: going against the flow.
Current Biology 8, R56-R58
Lord, J. M. and Roberts, L. M. (1998) Toxin entry: Retrograde transport through the
secretory system. J. Cell Biol.
140, 733-736
Muller, D., Vic, G., Critcheley, P., Crout, D. H. G., Lea, N. Roberts, L. M. and Lord, J.
M. (1998) Chemical
synthesis of globotriose and galabiose: relative stabilities of their complexes with
Escherichia coli Shiga-like toxin-1 as
determined by denaturation-titration with guanidinium chloride. J. Chem. Soc. Perkin
Trans. 1, 2287-2294
Frigerio, L. and Roberts, L. M. (1998) The enemy within: Ricin and plant cells. J. Exp.
Bot. 49, 1473-1480
Day, P. J., Lord, J. M. and Roberts, L. M. (1998) The deoxyribonuclease activity
attributed to ribosome-inactivating
proteins is due to contamination. Eur. J. Biochem. 258, 1-6
Jackson, M. E., Simpson, J. C., Girod, A., Pepperkok, R., Roberts, L. M. and Lord, J. M.
(1999) The KDEL
retrieval system is exploited by Pseudomonas exotoxin A, but not by Shiga-like toxin-1,
during retrograde transport
from the Golgi complex to the endoplasmic reticulum. J. Cell Sci. 112, 467-475
de Sousa, M., Roberts, L. M. and Lord, J. M. (1999) Restoration of lectin activity to an
inactive B chain by substitution
and mutation of the 2c subdomain. Eur. J. Biochem. 260, 355-361
Lea, N., Lord, J. M. and Roberts, L M. (1999) Proteolytic cleavage of the A subunit is
essential for maximal
cytotoxicity of Eschericia coli O157:H7 Shiga-like toxin-1. Microbiology 145, 999-1004
Noakes, K. L., Tiesserenc, H. T., Lord, J. M., Dunbar, P R., Cerundolo, V. and Roberts, L.
M. (1999) Exploiting
retrograde transport of Shiga-like toxin I for the delivery of exogenous antigens into the
MHC class I presentation
pathway. FEBS Letters 453, 95-99.
Simpson, J. C., Roberts, L. M., Romisch, K., Davey., J. Wolf, D. H. and Lord, J. M. (1999)
Ricin A chain utilises the
endoplasmic reticulum-associated protein degradation pathway to enter the cytosol. FEBS
Letters 459, 80-84.
McCloskey, N., Pound, J. D., Holder, M. J., Williams, J. M., Roberts, L. M., Lord, J. M.
and Gordon, J. (1999) The
extrafollicular-to-follicular transition of human B lymphocytes: induction of functional
globotriaosylceramides (CD77) on
high level threshold occupancy of CD40. Eur. J. Immunol. 29, 3236-3244.
Lord, J. M., Smith , D. C. and Roberts, L. M. (1999) Toxin entry: how bacterial proteins
get into mammalian cells.
Cellular Microbiology 1, 85-91
Girod, A., Storrie, B., Simpson, J. C., Johannes, L., Goud, B., Roberts, L. M., Lord, J.
M., Nilsson, T. and
Pepperkok, R. (1999) Evidence for a COP-1-independent transport route from the Golgi
complex to the endoplasmic
reticulum. Nature Cell Biology 1, 423-430.
Argent, R. H., Parrott, A. M., Day, P. J., Roberts, L. M., Stockley, P. G., Lord, J. M.
and Radford, S. E. (2000)
Ribosome-mediated folding of partially-unfolded ricin A-chain. J. Biol. Chem. 275,
9263-9269.
Lord, J. M., Davey, J., Frigerio, L. and Roberts, L. M. (2000) Endoplasmic
reticulum-associated protein degradation.
Seminars in Cell and Developmental Biology. 11, 1-5
Gordon, J., Challa, A., Levens, J. M., Gregory, C. D., Williams, J. M., Armitage, R J.,
Cook, J. P., Roberts, L. M.
and Lord, J. M. (2000) CD77-targeted therapy of human B lymphoma: CD40 ligand, Bcl-2, and
Bcl-xL spare group
Burkitt cells from killing via verotoxin-1 B chain but fail to protect against holotoxin.
Cell Death and Differentiation 7,
785-794.
Day, P. J., Roberts, L. M., Owens, S., Wesche, J., Olsnes, O. and Lord, J. M. (2000) Ricin
holotoxin binds
calreticulin both in vitro and in vivo. Implications for Golgi-to-endoplasmic reticulum
transport (2001) J. Biol.
Chem.(in press)
Frigerio, L., Jolliffe, N. A., di Cola, A., Paris, N., Neuhaus, J-M., Lord, J. M.,
Ceriotti, A. and Roberts, L. M. (2001)
The internal propeptide of the ricin precursor carries a sequence-specific determinant for
sorting to vacuoles. Plant
Physiol. (in press)
Roberts/Lord/Cook/Smith
1999